Effects of 2-Alkylamino-Substituted Dihydropyridines on Rabbit Jejunum

Authors

  • Bibi Fatemeh Anaraki-Firooz Biotechnology and Pharmaceutical Sciences Research Center, Postal Code 9196773117, Bu-Ali Square, Mashhad, Iran
  • Farzin Hadizadeh Department of Medicinal Chemistry, Faculty of Pharmacy, Mashhad University of Medical Sciences, P.O.Box 91775-1365 , Mashhad, Iran Biotechnology and Pharmaceutical Sciences Research Center, Postal Code 9196773117, Bu-Ali Square, Mashhad, Iran
  • Syed Intasar Husain Taqvi Department of Pharmacology, Jinnah Medical and Dental College, Karachi, Pakistan
Abstract:

      In order to investigate the effects of dimethylamino substituent at postion 2 of the dihydropyridine nucleus on its activity, dialkyl 1,4-dihydro-2-[2-(dimethy- lamino) ethyl]-6-methyl-4-(1-benzyl-2-alkylthio-5-imidazolyl)-3,5-pyrdinedicar- boxylates (6a-f) were synthesized. The synthesis was started from dialkyl 1,4- dihydro-2,6-dimethyl-4-(1-benzyl-2-alkylthio-5-imidazolyl)-3,5-pyridinedicar- boxylates (5a-f) which their synthesis and effects as calcium channel antagonist on guinea-pig ileum has been reported previously. Rabbit jejunum was used to determine the relaxant or antagonistic activity of the synthesized compounds. Some of the compounds (6c-e) inhibited the spontaneous contractile activity of jejunum, dose-dependently and completely, while high-K+ contracted tissues were relaxed partially.  

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Journal title

volume 1  issue 1

pages  27- 31

publication date 2005-01-01

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